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20 In the Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE), a multicenter international study, 749 out of 2161 (34.6%) patients with COPD Global initiative for Obstructive Lung Disease (GOLD) 4 stages II-IV had CB, and its prevalence increased with greater COPD severity (30.8%, 37%, and 40% in COPD GOLD stage II, III, and IV, respectively)

13 A 2017 study found that the use of smokeless tobacco was most commonly associated with men younger than 60 who possess less than a college degree, earn at least $25,000 but less than $50,000 annually, and live in the Midwestern or Western US

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